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Figure 3 Endothelium-dependent vasodilation in aortic rings of sedentary mice after (A) five weeks of singularization (n = 6) compared with mice living in groups of five animals per cage (moving mice, n = 6) and (B) after nine weeks of singularization (n = 7) compared with moving mice (n = 5) and with sedentary (n = 7) and moving mice (n = 5) that underwent the exercise program. Physical inactivity induced by singularization resulted in a significant impairment of endothelium-dependent vasorelaxation (* = p < 0.001, analysis of variance). Three weeks of exercise completely reversed this impairment, whereas exercise training had no effect on endothelium-dependent vasodilation in moving mice.