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Figure 5 Bar graphs showing concentration-dependent (upper left) and time-dependent (upper right) effects of incubation of rabbit carotid arteries with lysophosphatidylcholine (LPC) on dilator responses to acetylcholine (1 µM). The bottom panels show restoration of dilator responses after washout of 50 µM LPC (left panel) and 100 µM LPC (right panel). Values (mean ± SEM, n = 4 to 5) are percent change from a phenylephrine (1 µM)-induced preconstricted diameter of 2.0 ± 0.1 mm. *p < 0.001 vs. control; analysis of variance.