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Figure 4 Bar graphs showing effects on aortic tissue cholesterol content (left panel) and acetylcholine (1 µM)-induced maximal vasodilator responses (right panel). Values are mean ± SEM. *p < 0.001 vs. apoliprotein E (ApoE); **p < 0.05 vs. ApoE, analysis of variance. A significant inverse correlation between aortic tissue cholesterol content and maximal vasodilator responses to acetylcholine was observed (Pearson's r = –0.88, p < 0.05). DPPC = 1,2-dipalmitoyl-sn-3-phosphoglycerocholine; WT = wild-type.