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Figure 1 Schema of the experimental protocols are shown. In the mice experimental protocol (A), three groups of mice were studied: normal wild-type control, untreated hypercholesterolemic (HC) apolipoprotein E-null mice (ApoE), and treated HC ApoE-null mice. The types of studies and treatment interventions are shown. See text for details of rabbit experiments (B). Apo A-I_M = apolipoprotein A-I_Milano; Apo A-I_WT = apolipoprotein A-I wilt-type; DMPC = dimyristylphosphatidylcholine; DPPC = 1,2-dipalmitoyl-sn-3-phosphoglycerocholine; HDL = high-density lipoprotein; LDL = low-density lipoprotein; LPC = lysophosphatidylcholine.