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Figure 3 Focal macrophage density results. (a) Optical coherence tomography (OCT) image of a rupture site (outlined in red) overlying a lipid-rich plaque (LP). The * represents guide wire shadow. A 500 µm scale bar is seen in the top right-hand corner. (b) Bar graph representing mean macrophage density at sites of rupture, corresponding to outlined segment in panel a, compared with the rest of the plaque. Standard error bars are represented. (c and d) Receiver operating characteristic curves for surface and subsurface macrophage density for prediction of an acute coronary event at culprit sites (panel c) and remote sites (panel d). Areas under curve (AUC) for surface and subsurface macrophage density and the p value are noted in the insert.