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Figure 1 Fibrous cap segmentation and macrophage density images for lipid-rich plaques. (a) A normalized standard deviation (NSD) image demonstrating high macrophage density (blue red) at a site of disruption (arrow) within a lipid-rich plaque (LP). The * represents guide wire shadow artifact. (b) Optical coherence tomography (OCT) image of an LP. The * represents guide wire shadow artifact. A 500 µm scale bar is shown in the top right-hand corner. (c) Outline (red) of the segmented fibrous cap of the OCT image depicted in panel b. (d) Normalized standard deviation image superimposed over a standard intensity image shows locations (blue red) corresponding to increased macrophage density. The color scale bar represents the color mapping of the NSD parameter.