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Figure 6 Infarct size in in situ rabbit hearts. All animals had a 45-min coronary occlusion and 3-h reperfusion. Open circles represent individual experiments, closed circles depict group means with SEM. Four postconditioning cycles resulted in significant salvage. A single preconditioning (PC) cycle of 5-min occlusion/10-min reperfusion before the 45-min ischemia also was protective. The combination of ischemic postconditioning and preconditioning resulted in even greater protection than either alone. *p < 0.05 versus control; **p < 0.05 versus PC and four cycles.