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Figure 4 Infarct size in in situ rabbit hearts. All animals had a 30-min coronary occlusion and 3-h reperfusion. Open circles represent individual experiments, closed circles depict group means with SEM. Multiple cycles of immediate postconditioning limited infarct size, whereas glibenclamide (Glib), 5-hydroxydecanoate (5-HD), PD98059, and N-nitro-L-arginine methyl ester (L-NAME) blocked their protection. The tool drugs alone had no effect. *p < 0.05 versus other groups.