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Figure 3 Infarct size in in situ rabbit hearts. All animals had a 30-min coronary occlusion and 3-h reperfusion. Open circles represent individual experiments, closed circles depict group means with SEM. Both four and six immediate postconditioning cycles protected ischemic hearts, whereas delayed postconditioning elicited no protection. PD98059 did not block the protective effect of ischemic preconditioning. *p < 0.05 versus control.