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Figure 3 Example of systolic transbanding pressure gradient as a function of FloWatch regulation range as obtained in one minipig. At implantation (week 0) the FloWatch was adjusted to get the curve. Afterward, the degree of adjustment was set to 20% (= starting working point, in white). After one week, natural growth and cardiovascular adaptation lead to the second curve (= arrival working point, in black). After full-range regulation to get the curve, the degree of regulation was again set to 20% (= working point). Two weeks later, a slower cardiovascular adaptation leads to the third curve. Then the degree of adjustment was increased to 35% (= starting working point, in white). This augmented load induces an important cardiovascular adaptation, which leads to the curve at week 5 (solid line). At week 5, the degree of regulation was diminished to 20%, which induces no more cardiovascular adaptation for the following 7 weeks.