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Figure 3 (a) Effects on perfusion of adenovirus-encoding vascular endothelial growth factor gene (Ad.VEGF) or adenovirus-encoding angiopoietin-1 gene (Ad.Ang-1) injection in normal nonischemic ears; Ad.Ang-1 does not increase perfusion, while VEGF transiently increases flow, compatible with an inflammatory response. (b) The Ang-1-mediated increase in flow in ischemic ears is abolished when Ad.Ang-1 is injected concomitantly with adenovirus-encoding soluble VEGF receptor gene [Ad.Flt(1-3)-Fc], which encodes a soluble VEGF receptor that binds to and abolishes VEGF signaling. Ad.Null = control adenovirus without transgene insert.