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Figure 2 (a) Laser Doppler images eight weeks after ligation, before recombinant vector injection, and at indicated times after injection. In angiopoietin-1 (Ang-1)-treated animals, progressive recovery of perfusion occurs. After adenovirus-encoding vascular endothelial growth factor gene (Ad-VEGF) injection, a significant flow increase peaks at seven days and then gradually falls to below baseline by four weeks. (b) Effects of adenovirus-encoding Ang-1 gene (Ad-Ang-1), Ad-VEGF, and control adenovirus without transgene insert (Ad.Null) on tissue perfusion. The respective adenovirus vectors were injected intradermally eight weeks after ligation into both left and right ears of eight animals in each group. The flux index measured after injection was expressed as the percentage of the flux index immediately before injection. Values expressed as mean ± SD.