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Figure 3 Tissue factor (TF) expression in monocytes (CD14⁺ cells) was induced ex vivo by either 2 mmol/l thrombin receptor activator protein (TRAP) (A and B) or 10 mmol/l lipopolysaccharide (LPS) (C and D). The administration of NCX-4016 either alone or in combination with acetylsalicylic acid (ASA) reduced TF expression compared with placebo and ASA alone, as assessed by flow-cytometry and measuring the percentage of positive cells and fluorescence intensity (MIF). n = 12. *p < 0.05 LPS or TRAP vs. untreated cells; **p < 0.05 NCX-4016 vs. LPS or TRAP; p < 0.05 NCX-4016 and ASA vs. ASA alone.