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Figure 1 Effect of NCX-4016 and aspirin (ASA) on gastric mucosa as evaluated by endoscopy after the administration of NCX-4016, ASA, or both drugs for 21 days (A). NCX-4016 administration was associated with less extended gastric damage, compared with aspirin alone, as assessed using a modified Lanza's score. Both aspirin and NCX-4016 reduced the content of prostaglandins E2 (PGE₂) and F₂ (PGF₂) in the gastric mucosa (B). Means and standard errors, n = 12; *p < 0.001 vs. placebo; **p < 0.001 vs. ASA alone.