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Figure 6 Effect of a four months' lasting oral treatment with isosorbide mononitrate (ISMN) on vasorelaxations to ISMN. There was a rightward shift of the ISMN concentration response curve in cholesterol chow (CHOL)-ISMN as compared with controls and with CHOL (*p < 0.0001, each). This significantly less vasodilator response to ISMN indicates the development of nitrate tolerance in CHOL-ISMN.