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Figure 5 Effect of a four months' lasting oral treatment with isosorbide mononitrate (ISMN) on changes of vasorelaxations to the nitric oxide (NO) donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP) induced by hypercholesterolemia. The significant reduction of the vascular sensitivity against NO-dependent vasodilation induced by SNAP (rightward-shift, *p < 0.0001, control vs. cholesterol chow [CHOL]) was partially reversed by ISMN (CHOL vs. CHOL-ISMN: #p < 0.001).