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Figure 4 Effect of a four months' lasting oral treatment with isosorbide mononitrate (ISMN) on changes of endothelium-dependent vasorelaxation induced by hypercholesterolemia in (A) endothelium-intact aortic rings. The significant impairment of endothelium-dependent vasodilation in cholesterol chow (CHOL) as compared with controls was partially reversed by ISMN (*p < 0.001 CHOL vs. CHOL-ISMN; #p < 0.001 CHOL-ISMN vs. control). In (B) endothelium-denuded rings, acetylcholine induced vasoconstrictions.