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Figure 1 Effect of a four months' lasting oral treatment with isosorbide mononitrate (ISMN) on changes of aortic superoxide induced by hypercholesterolemia. Given are the cumulative counts/mg tissue measured during incubation with 5 µM lucigenin. The significant increase of superoxide in cholesterol chow group (CHOL) was completely abolished by treatment with ISMN (*p < 0.01 CHOL vs. control and CHOL-ISMN).