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Figure 5 Renin-angiotensin system inhibition and urine bicyclo-prostaglandin E2 (PGE2). High-sensitivity C-reactive protein was determined in urine samples from patients treated with either 20 mg enalapril or 300 mg irbesartan and normalized to serum creatinine levels. All patients received 100 mg acetyl salicylic acid. Prostaglandin E2 was determined by enzyme-linked immunosorbent assay. Both treatment regimens had no significant impact on urine bicyclo-PGE2, which is predominantly secreted by platelets, indicating a cyclo-oxygenase-independent mechanism. White bars = enalapril; black bars = irbesartan.