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Figure 5 Hemodynamic parameters under acute dobutamine challenge in increasing doses in the intact, closed-chest animal. (A) Left ventricular systolic peak pressure (LVP). (B) Maxima of the first derivative of left ventricular pressure (dP/dt_max). Solid squares = nontransgenic (NTG); open squares = transgenic (TG). *p < 0.05 TG versus NTG (n = 4 or 5 per group).