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Figure 2 (A) Systolic blood pressure after osmotic pump implantation (n = 9 to 11). (B) Ratio of left ventricular weight to body weight two weeks after pump implantation. Solid bars = nontransgenic (NTG); open bars = transgenic (TG). *p < 0.05 TG versus NTG. p < 0.05 versus respective vehicle group. p < 0.05 24 h versus 2 weeks (n = 8 to 12). (C) Hematoxylin-eosin–stained 5-µm sections of lung tissue. Note perivascular edema and engorged alveolar capillaries filled with erythrocytes in the TG lung (arrows).