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Figure 1 Cumulative percentage of patients terminating atrial fibrillation (AF) after infusions of placebo, 0.5 and 1.0 mg/kg RSD1235, or 2.0 and 3.0 mg/kg RSD1235 in patients with recent onset AF. Efficacy was significantly higher after 2 + 3 mg/kg RSD1235 than after placebo (p = 0.0003) and was significantly different between the two RSD1235 (p = 0.002) dosing regimens. The median time for termination of AF was 11 min from the start of the first infusion in the RSD1235 treatment groups.