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Figure 2 Pedigrees of hypertrophic cardiomyopathy (HCM) families with TNNI3 mutations. Squares = male family members; circles = female family members; symbols with slash = deceased individuals; open symbols = unaffected individuals; solid symbols = individuals affected; question mark = unknown clinical status; plus sign = presence of mutation; minus sign = absence of mutation. No clinical data were available in H375, II:6, but she was assumed to have HCM due to the fact that she was an obligate mutation carrier and had symptoms of disease preceding her unexplained sudden death.