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Figure 3 Cardiac ankyrin repeat protein (CARP), atrial natriuretic factor (ANF) and OPN are molecular markers of cardiac hypertrophy increase after AngII infusion. (A) Ventricular CARP and ANF expression are upregulated in both WT and OPN^–/– groups after four days of AngII (2.5 µg/kg/min) infusion. (B) Ventricular CARP returns to baseline but ANF remains upregulated after three weeks of AngII (2.5 µg/kg/min) infusion in both WT and OPN^–/– groups. (C) Ventricular OPN messenger ribonucleic acid expression in WT mice at four days after AngII infusion returns toward baseline by three weeks post-infusion. Other abbreviations as in Figure 1.