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Figure 3 Bar graphs summarizing the mean data of myocardial [¹⁸F]-2-deoxy-2-fluoro-D-glucose (FDG) uptake in GLUT4-null and wild-type mice (expressed as standard uptake values [SUVs], y-axis), using quantitative analysis of (A) in vivo positron emission tomography imaging and (B) in vitro gamma-counter tissue biodistribution studies. The positron emission tomography study was performed under the following conditions: baseline, simultaneous injection of insulin and FDG, and 60-min delay. The gamma-counter biodistribution study provides a more detailed time course of insulin-stimulated FDG uptake as 30-min and 120-min delay times points were also investigated. *p < 0.05 for comparisons with baseline values. p < 0.05 for comparisons between GLUT4-null and wild-type animals in each experimental condition. GLUT = glucose transporter.