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Figure 2 Representative positron emission tomography images obtained in wild-type and GLUT4-null mice under each of the experimental conditions. At baseline, no myocardial [¹⁸F]-2-deoxy-2-fluoro-D-glucose (FDG) activity was detected in the cardiac area of either animal. After simultaneous injection of insulin and FDG, the wild-type mouse presented with increased radiotracer uptake in the cardiac area (arrow), whereas no activity was identifiable in the GLUT4-null mouse. After 60 min, both animals had conspicuous myocardial FDG uptake of comparable intensity. GLUT = glucose transporter.