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Figure 3 Effects of peroxisome proliferators-activated receptor-alpha activator on the hydroxyproline content and procollagen messenger ribonucleic acid (mRNA) expression in DOCA-salt hypertensive rats. The hydroxyproline content (A) and expression of procollagen I (B) and III (C) mRNA levels are compared among the three groups: UN control (n = 6), DOCA-V (n = 7), and DOCA-F (n = 8). Expression of mRNA was determined by reverse-transcription polymerase chain reaction, and procollagen mRNA expression was corrected by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The DOCA-F results are compared with UN control or DOCA-V and shown as the mean value ± SEM. *p < 0.05 vs. UN control, **p < 0.01 vs. UN control, p < 0.05 vs. DOCA-V. Abbreviations as in Figure 1.