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Figure 2 Data were log-transformed before analysis. For ease of interpretation, the mean values ± SEM were transformed from the log scale back to the usual scale (mg/dl) in 10 subjects undergoing 88 h of acute total sleep deprivation. Overall p < 0.03 by mixed-models analysis of variance on log-transformed data; each subsequent day is significantly elevated (each p < 0.05) from baseline. The upper portion of the graph represents the boundary separating the low- and mild-risk quintiles of C-reactive protein (CRP) derived from analysis of >5,000 apparently healthy Americans (16). BL = baseline; Dep = deprivation.