Click on image to view larger version.

Figure 4 The intravascular ultrasound (IVUS) images of a left carotid artery showing atheroma enhancement by anti-intercellular adhesion molecule (ICAM) conjugated echogenic immunoliposome (ELIP). (a) After saline injection, (b) 5 min after 5 mg unconjugated ELIP, and (c) 5 min after 5 mg ICAM-conjugated ELIP. Notice the additional enhancement of the adventitia outside the area highlighted by the arrows, indicating adventitial enhancement by ELIP, as confirmed by immunohistochemistry (see Fig. 1). Arrows indicate enhanced intima/atheroma. Abbreviations as in Figure 2.