Click on image to view larger version.

Figure 2 A is a low-power view of the longitudinally cut proximal left anterior descending coronary artery from a dog assigned to receive eptifibatide + rt-PA in Phase II. There is virtually no visible thrombus in marked contrast to that seen in Figure 1. B and E are high-power views of the small thrombus (arrow) showing a few scattered platelets adhering to the minimal thrombus. C and F are high-power views of an area of the vessel severely damaged from crush injury with absence of endothelium and exposure of the underlying collagen with only an occasional platelet adhering to the collagen and rare red cells. D and G are high-power views from a more distal area of the vessel with focal loss of endothelium, demonstrating only rare platelets adhering to the underlying surface. Compared to Figure 1, high-power views F and G demonstrate a marked reduction in the number of platelets adhering to two different segments of comparable vessel wall injury.