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Figure 1 A is a low-power view of the longitudinally cut proximal left anterior descending coronary artery from a dog assigned to receive eptifibatide alone (in Phase II) showing presence of thrombus at the site of the side branch catheter through which thrombin was infused. Just distal to the thrombus, the traumatized left anterior descending coronary artery is seen. B and E are high-power views of the thrombus, showing platelet aggregation with fibrin strands and an occasional red cell. (C and F are high-power views of an area of the vessel severely damaged from crush injury, demonstrating disrupted endothelium covered by a thick layer of aggregated platelets within a fibrin mesh. D and G are high-power views from a more distal, less severely injury vessel segment showing a fibrin mesh with platelet adherence to the underlying collagen at the site of vessel injury.