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Figure 3 Hemodynamic and gas-exchange response to inhaled nitric oxide (NO), infused PGI₂, and oral sildenafil in patients with lung fibrosis and pulmonary hypertension. Deviations from preintervention baseline are displayed for inhaled NO, infused prostacyclin (PGI iv), and oral sildenafil (Sil oral). CO = cardiac output; mPAP = mean pulmonary arterial pressure; mSAP = mean systemic arterial pressure; PaO ₂ = partial pressure of arterial oxygen (changes in mm Hg); PVRI = pulmonary vascular resistance index; PVR/SVR ratio = ratio of pulmonary to systemic vascular resistance (adapted from Ghofrani et al., Lancet 2002;360:895–900).