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Figure 3 Mitochondrial score of biopsies taken from either hibernating segments (hibernation), or from normally contracting myocardium (control), before cardiac arrest, or 10 min after reperfusion. Grading scale was: 0 = normal; 1 = initial swelling (separation of cristae, decreased matrix density); 2 = more marked swelling than in grade 1; 3 = massive swelling with architectural disruption; and 4 = findings as in grade 3 plus rupture of inner and outer mitochondrial membranes. Note the shift from normal appearance to altered morphology occurring with ischemia and reperfusion. This shift is less pronounced in biopsies from hibernating segments. Data are mean ± SE of percent mitochondria scored. Values in parentheses are the number of mitochondria scored for each set. *p < 0.05 vs. control.