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Figure 2 Effects of ischemia-reperfusion. (A) Normally contracting area of the anterior wall (control patient) before cardiac arrest (x10,000). Note overall preservation of structure. Sarcomeres are in register; mitochondria show normal morphology with tightly packed cristae and intact membranes. Sarcolemma is preserved. (B) Normally contracting area of the anterior wall (control patient) 10 min after reperfusion (x10,000). Note intracellular and intermyofibrillar edema; mitochondria appear massively swollen, with alteration of cristae and frequent disruption of inner and outer membranes. (C) Non-contracting area of the anterior wall (hibernation patient) before cardiac arrest (x12,000). Sarcoplasmic reticulum is scarce, substituted by amorphous material. Some mitochondria show mild edema. (D) Non-contracting area of the anterior wall (hibernation patient) 10 min after reperfusion (x8,000). Mitochondria are well-preserved, and only mild edema is observed. RS = residual sarcomeres.