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Figure 3 (A) Bar graphs comparing New York Heart Association (NYHA) functional classes before and after the active treatment of heart failure (mean ± SEM). (B) Box plots of urinary biopyrrins/creatinine levels before and after the active treatment of heart failure. The horizontal line in the box represents the median value; the boxed area is the interquartile range; and the whiskers are the 10% to 90% range.