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Figure 1 Potential pathways and mechanisms for cigarette smoking-mediated cardiovascular dysfunction. The bold boxes and arrows in the flow diagram represent the probable central mechanisms in the complex pathophysiology of cigarette-smoking-mediated athero-thrombotic disease. H2O2 = hydrogen peroxide; METC = mitochondial electron transport chain; NADPH = nicotinamide adenine dinucleotide phosphate reduced form; NOS = nitric oxide synthase; ONOO– = peroxinitrite; O·2– = superoxide.