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Figure 1 Beta-adrenergic receptor responsiveness to isoproterenol (ISO) stimulation. In the basal condition, maximum rate of rise in left ventricular (LV) pressure (dP/dt) was lower in animals with myocardial infarction (MI) than in shams. An increase in dP/dt under ISO stimulation was attenuated in untreated MI animals (MI/control [C]) but improved in candesartan-treated animals (MI/angiotensin II type 1 receptor blocker [ARB]). *p < 0.05 MI/ARB vs. MI/C by repeated measures analysis of variance; n = 4 in each group.