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Figure 3 Type I collagen messenger ribonucleic acid levels, collagen concentration, and matrix metalloproteinase (MMP)-13 protein expression in the left ventricle of sham-operated rats (Sham) and in the noninfarcted left ventricular myocardium of rats with extensive myocardial infarction (P MI): Effects of aldosterone receptor inhibition (E), ACE inhibition (T), or combined aldosterone and ACE inhibition (E+T). Mean ± SEM (n = 5 to 11). *p < 0.05 versus Sham; p < 0.05, p < 0.01, p < 0.001 versus P MI. GAPDH = glyceraldehyde-3-phosphate-dehydrogenase.