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Figure 4 Serial changes in plasma levels of plasminogen activator inhibitor (PAI) activity between the two conjunctive treatment groups. There is a significant difference in the time course of PAI activity between the two groups. Activity of PAI was increased similarly until 8 h in both groups. Then the level kept increasing until 24 h in the heparin group, although it was decreasing in the APC group. *p < 0.05 vs. pre in both treatment groups. p < 0.05 between the two groups at each sampling point. The center lines in the columns show the median value, and the box plots show the ranges between the 25th and 75th percentile values. The bars attached to the columns show the ranges between the 10th and 90th percentile values. Solid columns = APC (activated protein C) group; open columns = heparin group.