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Figure 1 Induction of chronic myocardial ischemia using a reduction stent. (A) A stent graft is ligated in the center. (B) The stent is crimped on balloon and inflated at 14 atm; it remains unexpanded at the site of the ligature, resulting in an hourglass-shaped stenosis. (C) Postmortem angiogram at day 28. The arrow indicates the location of the reduction stent, which is totally occluded. Collaterals are visible connecting the proximal left anterior descending artery (LAD) and diagonal branches to the distal LAD.