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Figure 3 The mechanism responsible for J-wave–related arrhythmogenesis. (A) Polymorphic ventricular tachycardia (VT) in a patient with prominent J-waves. Reprinted from Aizawa et al. (5), with permission. (B) Polymorphic VT initiated by phase 2 re-entry in a canine right ventricular wedge in the presence of 2.5 µmol/l pinacidil. The action potentials (APs) were simultaneously recorded from two epicardial sites (Epi 1 and Epi 2) and one endocardial (Endo) site. A loss of the AP dome in Epi 1, but not in Epi 2, led to phase 2 re-entry capable of initiating polymorphic VT.