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Figure 2 Possible mechanisms responsible for ST-segment elevation. (A) The concept of "injury current." The "injury zone" in the epicardium, with a reduction in resting membrane potential, produces an injury current during the resting phase that should result in TQ depression instead of ST-segment elevation. (B) The concept of "loss of action potential (AP) dome or plateau amplitude." A difference in the AP plateau amplitude generates a transmural voltage gradient that could manifest as ST-segment displacement.