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Figure 1 (A) Representative laser Doppler blood flow (LDBF) images at days 7, 14, and 28 are shown. (B) Before and after surgery, the hindlimb LDBF ratio did not differ among the three groups. The control group revealed progressive recovery of the ischemic/normal LDBF ratio within 28 days after induction of limb ischemia. However, the LDBF ratio was lower in the hypercholesterolemia (HC) group than in the controls. In the HC + Folate group, the LDBF ratios were significantly improved compared with the HC group; n = 6 in each group. *p < 0.05; **p < 0.01 vs. control; p < 0.05; p < 0.01 vs. HC.