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Figure 1 Schematic of the QUASAR study design. Q = quinapril; R = randomize. After a 2- to 4-week single-blind placebo period (Period 1) patients were randomly assigned to two groups. Group 1 received double-blind placebo for 8 weeks (Period 2) and then double-blind Q 80 mg/day for 8 weeks (Period 3). In the latter, there was a 1 week dose titration from 40 to 80 mg/day. Group 2 received double-blind Q 40 mg/day for 8 weeks (Period 2) followed by double-blind Q 40 mg/day for an additional 8 weeks (Period 3).