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Figure 4 Mutation detection in DCM 035. (A) Denaturing high performance liquid chromatography (DHPLC) analysis of exon 4 identifies an abnormal DHPLC pattern (top panel), which is absent in controls (bottom panel). (B) The deoxyribonucleic acid (DNA) sequence analysis of genomic DNA identifies a C to T base substitution at position 638. (C) Blast homology analysis of Cypher/ZASP amino acid sequence for residue T213.