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Figure 5 Significant attenuation of proinflammatory cytokine expression and nuclear factor-kappa B (NF-kB) activity in the heart of wild-type (WT) mice (n = 9 each) with viral myocarditis by Ang-II type 1-receptor (AT1R) blockade with candesartan (10 mg/kg per day). Myocardial cytokine mRNAs of TNF-alpha (A) and interleukin-1-beta (IL-1-beta) (B). (C) Densitometric analysis of the results expressed as arbitrary units of mean values ± SEM. Mean NF-kB activity in the infected WT mice treated with the vehicle is represented as 1. *p < 0.01. **p < 0.05.