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Figure 2 Skin blood flow during reactive hyperemia in normocholesterolemic and hypercholesterolemic subjects and before and during therapy with a statin (changes normalized to baseline flow). Hyperemic skin blood flow in hypercholesterolemic patients is reduced compared with healthy controls, *p < 0.0001 versus healthy volunteers and can markedly be increased by statin therapy, p = 0.0005 versus before treatment.