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Figure 3 Change and standard error of the mean from baseline to week 16 in Doppler right ventricle (RV) index in bosentan- and placebo-treated patients. The treatment effect was statistically significant for the combined treatment group (p = 0.034) and of borderline statistical significance for both 125 mg (p = 0.074) and 250 mg (p = 0.070) dose subgroups. Black bar = bosentan; white bar = placebo.