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Figure 1 Change and standard error of the mean from baseline to week 16 in right ventricle to left ventricle (RV:LV) diastolic areas ratio in bosentan- and placebo-treated patients. The treatment effect was statistically significant for combined dose group (p = 0.007) and for 125 mg (p = 0.015) and 250 mg dose subgroups (p = 0.026). Black bar = bosentan; white bar = placebo.