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Figure 1 Study schema. In dose-finding Part 1 (top, A), all patients received the same double-bolus regimen of eptifibatide (180/2/90) and were administered, in a randomized fashion, either half (0.27 mg/kg) or three-quarters (0.40 mg/kg) of the standard dose of tenecteplase (TNK). After completion of Part 1, all patients in Part 2 (bottom, A) received half-dose tenecteplase, whereas the second bolus dose of eptifibatide was randomly assigned (90 vs. 180 µg/kg). On the basis of the dose-finding results, the combination of eptifibatide 180/2/180 plus half-dose tenecteplase was selected for direct comparison to standard-dose tenecteplase in dose-confirmation (B). ACC/AHA = American College of Cardiology/American Heart Association; TIMI 3 = Thrombolysis In Myocardial Infarction grade 3 flow.